DRUGCOAT RL 100[ Sustained release - Solvent base ]
Ammonio Methacrylate Copolymer Type A, USP/NF
DRUGCOAT RL 100 is a copolymers of acrylic and methacrylic acid esters with
a high content in quaternary ammonium groups compare to DRUGCOAT RS 100. The ammonium groups are present as salts and make the polymers permeable.
Application:
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DRUGCOAT RL 100 is used for sustained-release formulations which release drug by diffusion
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The polymer can be used for coating the pellets or small particles to be filled in to capsules.
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They can be used for matrix structures produced by direct compression or wet granulation.
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Time-controlled release of active ingredient.
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Therapeutically customized release profiles.
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Can be used in hot melt process.
Characteristics:
Appearance
Slight Yellowish Solid
Odour
Faint Amine Like
Content
Not less than 97% of dry substance
LOD
Max. 3%
Assay
8.85 to 11.96 % ammonio methacrylate units on dry substance
Self Life
4 Years
Additives:
» Plasticizer
It is strongly recommended to add 10-20% plasticizer on dry polymer substance into the organic solutions of DRUGCOAT RL 100, to obtain films of adequate flexibility.
» Glidants
Glidants like talc, micronized amorphous silica and glycerol monostearate facilitate spray application to the cores.
» Pigments
Opaque white or colored coatings can be obtained by adding pigments like titanium dioxide, food colors and iron oxide.
Grades of DRUGCOAT RL 100 :
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DRUGCOAT RL 12.5:
Ready to use solution of DRUGCOAT RL 100 with 12.5 %( w/w) dry substance in organic solvent like Isopropyl Alcohol and Acetone.
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Characteristics:
Appearance
Colourless, clear to slightly cloudy solutions
Odour
Characteristic odour of Isopropyl Alcohol
Content
12.5% of dry Substance
Self Life
2 Years
Storage:
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DRUGCOAT RL 100
Store at controlled room temperature (USP, General Notices). Protect from moisture and storage temperature should not exceed 300C , preferably should be between 80C - 250C
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DRUGCOAT RL 12.5
Store in tightly closed containers. Protect from warm temperature (USP, General Notices)
Packaging:
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DRUGCOAT RL 100
10 kg net in paper fiber drum with polyethylene lining.
