DRUGCOAT E 100 |
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Amino Methacrylate Copolymer, USP/NF |
DRUGCOAT E 100 is a copolymer, cationic in character, based on dimethylaminoethyl methacrylate and neutral Methacrylic acid esters. It becomes water-soluble by forming salts with acids; thus film coatings produced from DRUGCOAT E 100 are soluble in gastric juice. Can perform much better than HPMC.
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Characteristics: |
| Appearance |
Slight Yellowish Solid |
| Odour |
Characteristic, amine like |
| Content |
At least 98% of dry substance |
| LOD |
Max. 2% |
| Self Life |
4 Years |
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Characteristics of the Film: |
DRUGCOAT E 100 lacquer films are colorless, transparent, pliant and elastic. They are soluble in acids as well as in natural and artificial gastric juices. They are soluble in buffer solutions within the pH range of 2-5. They are capable of swelling and are permeable in water and buffer solutions above pH 5.
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Application: |
- To avoid abrasion and powdering
- To improve handling stability
- To mask unpleasant taste of smell
- To improve keeping properties protection against moisture, light and air
- To improve appearance or for color identification
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- To improve keeping properties
- For closing or sealing purposes
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- For isolation of incompatible ingredients
- To improve keeping properties
- To influence drug release properties
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- For isolation of incompatible ingredients
- To improve the keeping properties
- To improve compression characteristics on tabletting (hardness, abrasion, covering)
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Additives: |
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It is strongly recommended to add 10-20% plasticizer on dry polymer substance into solutions of DRUGCOAT E 100, to obtain films of adequate flexibility. |
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| Glidants like talc, micronized amorphous silica and glycerol monostearate facilitate spray application to the cores. |
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| Opaque white or colored coatings can be obtained by adding pigments like titanium dioxide, food colors and iron oxide. |
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| Grades of DRUGCOAT E 100: |
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| Ready to use solution of DRUGCOAT E 100 with 12.5 %( w/w) dry substance in organic solvent like Isopropyl Alcohol and Acetone. |
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| Appearance |
Colourless, clear to slightly cloudy solutions |
| Odour |
Characteristic odour of Isopropyl Alcohol |
| Content |
12.5% of dry Substance |
| Self Life |
2 Years |
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Storage: |
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Protect from damp and moisture, Store at a temperature not exceeding 300C, preferably between 80C - 250C. Protect from moisture and warm temperatures. |
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Store in tightly closed containers. Protect from warm temperature (USP, General Notices) |
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Packaging: |
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10 kg net in HDPE drum with polyethylene lining. |
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25 kg net in HDPE carboy. |
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